Summary
Perimenopause is the period of time before the final menstrual cycle, which can last for up to 10 years. During perimenopause, there is a significant change in cerebral metabolism, resulting in a 20% decline in glucose uptake. Symptoms of perimenopause include hot flashes, night sweats, difficulties sleeping, anxiety, and changes in cognitive function. Biomarkers associated with perimenopause include hot flashes, night sweats, increased bone loss, and changes in cerebral metabolism. Hormone therapy is recommended during perimenopause to manage symptoms and reduce the risk of conditions like Alzheimer's disease.