What is GLP-1 & How Does It Reduce Appetite & Promote Weight Loss? | Dr. Andrew Huberman

There is a parallel activation of epinephrine adrenaline both from your adrenals and from an area in the brain called the locus ceruleus . So again and again , we see this in biology and in neuroscience that your brain and your body are acting in concert , they're acting together through mechanisms that either are independent , so separately in the brain and separately in the body , but directed towards a common goal or through communication between brain and body . And almost always that communication is going to be bidirectional body to brain and brain to body .

What is GLP-1 & How Does It Reduce Appetite & Promote Weight Loss? | Dr. Andrew Huberman

Ent er ic enteric nervous system . This is a component of your nervous system that you don't really have control over . It's autonomic or automatic GOP .

What is GLP-1 & How Does It Reduce Appetite & Promote Weight Loss? | Dr. Andrew Huberman

Because this recent category of drugs that's now hitting the market seems to adjust obesity or can help people with weight loss in order to help their health . And it's doing so by at least two mechanisms , one is within the brain and the other is within the gut and communication through the so called gut brain access . Because again , these inter neurons are communicating to the brain , the hypothalamus , by way of this , what's called the sympathy gastro spinal reticular hypothalamic pathway , you absolutely do not need to know all of that .

What is GLP-1 & How Does It Reduce Appetite & Promote Weight Loss? | Dr. Andrew Huberman

And it's doing so by at least two mechanisms , one is within the brain and the other is within the gut and communication through the so called gut brain access . Because again , these inter neurons are communicating to the brain , the hypothalamus , by way of this , what's called the sympathy gastro spinal reticular hypothalamic pathway , you absolutely do not need to know all of that . That's a mouthful , that's enough to make your mouth feel distended .

What is GLP-1 & How Does It Reduce Appetite & Promote Weight Loss? | Dr. Andrew Huberman

And by way of a pathway that goes from the gut up to the hypothalamus . This little cluster of neurons about the size of a marble that sits above the roof of your mouth is also suppressing appetite through brain mechanisms . So this is really beautiful , right ?