Testosterone & Testosterone Replacement Therapy (TRT) | Dr. Peter Attia & Dr. Andrew Huberman

And do you still use antibiotics ? Uh , um , sorry to try and lower SHBG because it's too potent . No , because it's just too complicated for patients .

Testosterone & Testosterone Replacement Therapy (TRT) | Dr. Peter Attia & Dr. Andrew Huberman

Mine is incredibly low . My SHBG is like kind of in the thirties , twenties to thirties . Um But from a hormone perspective , there's basically three hormones that run it .

Testosterone & Testosterone Replacement Therapy (TRT) | Dr. Peter Attia & Dr. Andrew Huberman

So he has a lot of the enzyme that converts testosterone into estradiol . You can lower estradiol a bit with an aromatase inhibitor and that can bring down SHPG . Now , again , these things individually are rarely enough to move the needle .

Testosterone & Testosterone Replacement Therapy (TRT) | Dr. Peter Attia & Dr. Andrew Huberman

That's very high because I think the upper range is somewhere around 5556 . So we would first backs stall for what's driving is SHBG . So there's basically three hormones .

Testosterone & Testosterone Replacement Therapy (TRT) | Dr. Peter Attia & Dr. Andrew Huberman

So genetics plays a huge role in this . There's no question that just out of the box , people have a different like set point for SHBG . Mine is incredibly low .