Testosterone & Testosterone Replacement Therapy (TRT) | Dr. Peter Attia & Dr. Andrew Huberman

So you were with and without an astro and five doses of testosterone . So now you basically had five testosterone levels plus or minus high or low estradiol . And the results were really clear that the higher your testosterone and the more your estradiol was in kind of that 30 to 50 range , the better you were .

Testosterone & Testosterone Replacement Therapy (TRT) | Dr. Peter Attia & Dr. Andrew Huberman

So now you basically had five testosterone levels plus or minus high or low estradiol . And the results were really clear that the higher your testosterone and the more your estradiol was in kind of that 30 to 50 range , the better you were . So , if estrogen was too low , even in the presence of high testosterone , the outcomes were , were , were uh less significant and this is 30 to 50 nanograms per de or not 30 to 50% of your , of one's testosterone .

Testosterone & Testosterone Replacement Therapy (TRT) | Dr. Peter Attia & Dr. Andrew Huberman

So , so the goal was how do I just give you more free testosterone ? So if , if a patient shows up and they've got a , a total testosterone of 900 nanograms per deciliter , which would place them at , you know , depending on the scale , you look at the scale we look at that would place you at about the 70th percentile , but your free testosterone is , you know , eight nanograms per deciliter . So that's pretty bad .

Testosterone & Testosterone Replacement Therapy (TRT) | Dr. Peter Attia & Dr. Andrew Huberman

And the results were really clear that the higher your testosterone and the more your estradiol was in kind of that 30 to 50 range , the better you were . So , if estrogen was too low , even in the presence of high testosterone , the outcomes were , were , were uh less significant and this is 30 to 50 nanograms per de or not 30 to 50% of your , of one's testosterone . Ok .

Testosterone & Testosterone Replacement Therapy (TRT) | Dr. Peter Attia & Dr. Andrew Huberman

FSHLH goes up in any man , the FSH and LH go up . But if a man still has testicular reserve , he'll make lots of testosterone in response to that . Um because that's the first order question we're trying to answer is do you , is your failure to make testosterone central or peripheral ?