It'll teach you all the basics of what are cytokines , what our mast cells , et cetera in any event , all these pro inflammatory molecules , those are being released . You've now got disruption of the gut microbiota as a consequence . The lining of the gut is disrupted and you develop at least transiently leaky gut .
So alcohol kills bacteria and it is indiscriminate with respect to which bacteria , it kills . So when we ingest alcohol and it goes into our gut , it kills a lot of the healthy gut microbiota . At the same time , the metabolism of alcohol in the liver , which you now understand that pathway involving n ad acetyl acetyl aldehyde and acetate , that pathway is pro inflammatory .
Again , low sugar varieties of all these things . Those are terrific at reducing inflammatory markers and at improving the gut microbiome , one could imagine that either inoculating oneself from some of the effects of alcohol , although I'd prefer that people just not drink alcohol chronically frankly , or if somebody's trying to repair their gut microbiome because they ingested a lot of alcohol or because they had a lot of these inflammatory cytokines for many years or even a short period of time . Regular ingestion of 2 to 4 servings of these fermented foods can be um quite beneficial .
So this is just terrible , right ? I mean , you take in something that disrupts two systems , the gut microbiota and it disrupts in two ways , it's killing the good gut microbiota and it's allowing the bad bacteria to move from the gut into the bloodstream . You've also got pro inflammatory cytokines coming from the liver and those converge or arrive in the brain and create a system in which the neural circuits cause more drinking .
Certainly that would work as well . Although I've sort of favored the discussion around fermented foods and replenishment of the gut microbiome mostly because there are more studies that have examined that in humans and because of the direct relationship that's been established between doing that and reducing negative markers within the inflamma to .
