But now you pointed out um biomarker and other stuff . So now if you look at any given time within that experiment and actually Joe went back and um had a separate cohort of mice very similar and so that he could take tissue samples . And of course , in this case , you have to sacrifice the mouse .
Um We started discussing that the rat experiments were done with caloric restriction and researchers gave reduced calorie consumption by 20% or 30% and get that food , the rats and then subsequently mice and they all lived longer . What is interesting is um in all those experiments , um the researchers came and gave this bolus of food at one time , whereas they are lit on fed mice or rats , they had access to food all the time . So they were eating all the time and then these rats uh were given 20% less .
So there is a famous experiment that was published last year by J Takahi Islam and it came out in science and that relates to caloric restriction . And we kind of started with this idea .
And we kind of started with this idea . Um We started discussing that the rat experiments were done with caloric restriction and researchers gave reduced calorie consumption by 20% or 30% and get that food , the rats and then subsequently mice and they all lived longer . What is interesting is um in all those experiments , um the researchers came and gave this bolus of food at one time , whereas they are lit on fed mice or rats , they had access to food all the time .
For example , hemoglobin , a one c equivalent of glucose control cholesterol , all this stuff , he could not find anything that predicted the benefit of caloric restriction . So that means in this experiment , whatever we know so far the predictor of longevity , none of them could predict whether this um see our only mouse which at throughout day and night , that mouse is going to live less than the night fed mouse that was going to live 35 25% extra . Does that mean that there are biomarkers related to longevity that we just haven't discovered yet ?
