For example , hemoglobin , a one c equivalent of glucose control cholesterol , all this stuff , he could not find anything that predicted the benefit of caloric restriction . So that means in this experiment , whatever we know so far the predictor of longevity , none of them could predict whether this um see our only mouse which at throughout day and night , that mouse is going to live less than the night fed mouse that was going to live 35 25% extra . Does that mean that there are biomarkers related to longevity that we just haven't discovered yet ?
Um We started discussing that the rat experiments were done with caloric restriction and researchers gave reduced calorie consumption by 20% or 30% and get that food , the rats and then subsequently mice and they all lived longer . What is interesting is um in all those experiments , um the researchers came and gave this bolus of food at one time , whereas they are lit on fed mice or rats , they had access to food all the time . So they were eating all the time and then these rats uh were given 20% less .
Yeah , exactly . So , we have done that experiment in mice and we don't see , um , difference in not only weight loss , many other markers . And I was telling you about this , um , Jor Taka paper where I told you that he allowed these mice to eat within two hours or 12 hours sub caloric diet two or 12 , 2 or 12 .
And we kind of started with this idea . Um We started discussing that the rat experiments were done with caloric restriction and researchers gave reduced calorie consumption by 20% or 30% and get that food , the rats and then subsequently mice and they all lived longer . What is interesting is um in all those experiments , um the researchers came and gave this bolus of food at one time , whereas they are lit on fed mice or rats , they had access to food all the time .
So that in many ways seems to mimic the human studies where they say , look , it doesn't really matter whether or not you use caloric restriction or , or you start your feeding window in the morning or start your feeding window in the evening or you , um , or you portion control for sake of weight , weight loss because you're taking a snapshot of that . And then another thing with the human study that we are referring to here , um , that in that human study , people are actually already eating within 10 hours window , habitually when they selected these people to have them enroll in the study . So they are already eating for 10 hours and fasting for uh 14 hours .
