But when they fed mice during night time , when they're supposed to eat , and they're seeing this getting the same number of calories within 12 hours or two hours . And the mice live 35% longer than they control 35% longer . So scale to human lifespan , which , you know , we don't know but , but a 35% longer would mean that um and again , no one knows .
So they were eating all the time and then these rats uh were given 20% less . And what happens is this mice or rats ? Then I'm going to take that less food , which is restaurant now and just eat a little bit of uh lunch and then snack after three hours or snack .
So now if you look at any given time within that experiment and actually Joe went back and um had a separate cohort of mice very similar and so that he could take tissue samples . And of course , in this case , you have to sacrifice the mouse . And he looked for um he did a lot of molecular analysis with non markers .
Right . Whereas with mice , you have some sense of when the mortality was likely to occur . So what , what can we say about time restricted feeding and longevity in terms of biomarkers or in terms of any other indication that people who start and stop their feeding window at a consistent time , somewhere between eight and 12 hours per 24 hour cycle are tilting the scales towards living longer as opposed to living shorter .
For example , hemoglobin , a one c equivalent of glucose control cholesterol , all this stuff , he could not find anything that predicted the benefit of caloric restriction . So that means in this experiment , whatever we know so far the predictor of longevity , none of them could predict whether this um see our only mouse which at throughout day and night , that mouse is going to live less than the night fed mouse that was going to live 35 25% extra . Does that mean that there are biomarkers related to longevity that we just haven't discovered yet ?
