It doesn't matter what , but the mouse realized there is something there that makes me feel good and that's what I want . And that is the fundamental basis of our unquenchable desire and our craving for sugar and is mediated by the gut brain axis . The first clue is that it takes a long time to develop immediately suggesting a post ingested effect .
This has a profound impact on the effect of ultimately artificial sweeteners in curbing our appetite . Our craving our insatiable desire for sugar since they don't activate the gut brain axis , they'll never satisfy the craving for sugar like sugar . That and the reason I believe that artificial sweeteners have failed in the market to curb our appetite .
The first clue is that it takes a long time to develop immediately suggesting a post ingested effect . So we reason if this is true and is the gut brain axis that's driving sugar preference , then there should be a group of neurons in the brain that are responding to post ingested sugar . And lo and behold , we identify a group of neurons in the brain that does this and these neurons receive their input directly from the gut brain axis from other neurons .
OK . Now let me just take it one step further and this now sugar molecules activate this unique gut brain circuit that now drives the development of our preference for sugar . Now , a key element of this circuit is that the sensors in the gut that recognize the sugar do not recognize artificial sweeteners at all .
Let me tell you it about the gut brain axis and our insatiable appetite for sugar and fat , insatiable for sugar and quenchable for fat . And this is a story about the fundamental difference between liking and wanting like in sugar is the function of the taste system .
