How Marijuana Affects the Brain & Body | Dr. Andrew Huberman

Now , let's take a step back into the real world and evaluate or think about what happens when somebody smokes cannabis or ingests cannabis by way of edible or tincture or something of that sort . Cannabis is very fast to enter the bloodstream . In fact , within 30 seconds , it's going to enter the brain and permeate throughout the brain and body .

How Marijuana Affects the Brain & Body | Dr. Andrew Huberman

Ok . So if someone smokes cannabis or they ingest cannabis very rapidly gets into the bloodstream and the components that are psychoactive , get into the bloodstream and are immediately able to access neurons and other cells and start having these effects of parking at those endogenous cannabinoid receptors and impacting the signaling between neurons , which leads to the subjective effects of cannabis including THC and CBD . So let's talk about what those different subjective effects are .

How Marijuana Affects the Brain & Body | Dr. Andrew Huberman

So we have kind of a seesaw effect here where the same compound is increasing mood and alertness and focus in the prefrontal cortex and is decreasing stress and threat detection in the Amygdala . And that's one of the reasons why especially the sativa varieties of cannabis allow people to enter these states of focus . Some might even say flow .

How Marijuana Affects the Brain & Body | Dr. Andrew Huberman

Now , this is all changing quite a lot nowadays because of the commercialization of THC and CBD products and cannabis in a number of different areas including in the United States . But still many people are ingesting cannabis THC CBD through sources where they don't really know how much they're bringing into their system . And so whether or not someone gets incredible anxiety relief , enhanced sense of mood and focus and well being pain relief , et cetera or whether or not they have full blown panic attacks , et cetera is very hard to predict based on dosage information alone .

How Marijuana Affects the Brain & Body | Dr. Andrew Huberman

So I know that a number of people depend on whether or not they get tested for work or for sport or otherwise for cannabis or CBD . And THC don't take this as a strict number , but typically if one ingests CBD or THC smokes cannabis ingests by orally , et cetera , it doesn't matter , it's gonna stay in that fatty tissue and can be detected for at least as long as 80 days after ingestion . And there's a whole industry as to , you know , how to accelerate the clearance .