What's the History of Lithium? How Does It Treat Bipolar Disorder? | Dr. Andrew Huberman

And so he quite appropriately asked , maybe the lithium alone is having this calming effect on these guinea pigs . And indeed , that was the case when he did the proper control experiment and injected only lithium solution into these guinea pigs . They calm down from there .

What's the History of Lithium? How Does It Treat Bipolar Disorder? | Dr. Andrew Huberman

But he knew that that solution of lithium ate contained not just the uric acid but it also contained lithium . And so he quite appropriately asked , maybe the lithium alone is having this calming effect on these guinea pigs . And indeed , that was the case when he did the proper control experiment and injected only lithium solution into these guinea pigs .

What's the History of Lithium? How Does It Treat Bipolar Disorder? | Dr. Andrew Huberman

We're adding lithium to the uric acid . We're injecting this into guinea pigs . This is getting pretty wild and pretty weird , but this is medicine and from time to time this is medicine and science .

What's the History of Lithium? How Does It Treat Bipolar Disorder? | Dr. Andrew Huberman

This is a lot of details , but this is important because what he eventually found is that when he diluted the uric acid with lithium and created lithium ate , lithium ate could actually calm down these guinea pigs that were injected with the toxic urea . He also found that lithium ate , had a generally calming effect on these guinea pigs . So now we're really off in crazy territory , right .

What's the History of Lithium? How Does It Treat Bipolar Disorder? | Dr. Andrew Huberman

OK . This is a lot of details , but this is important because what he eventually found is that when he diluted the uric acid with lithium and created lithium ate , lithium ate could actually calm down these guinea pigs that were injected with the toxic urea . He also found that lithium ate , had a generally calming effect on these guinea pigs .