The women who are having the most symptoms in perimenopause menopause , the hot flashes , the night sweats , the difficulties sleeping . Those are the ones who have the most significant cerebral hypometabolism . So it's almost like a um I don't , I don't want to scare people with this language , but it's , it's a low level or let's call it pseudodementia of sorts .
So , um there's this whole period of perimenopause and what's most fascinating to me and we've got to talk about this either today or another time is that there is this massive massive change that happens in the female brain that people are not talking about enough . And so looking at the work of Lisa Mosconi at Cornell from uh starting around age 40 there is this massive change in cerebral metabolism . So you can do FDG PE T scans .
But then of course , right . I mean , the brain is just incredibly metabolically demanding organ . You deprive neurons of fuel sources .
I think I think so because we believe that the system is regulated by estrogen . So the decline in estrogen starting around age 4043 is kind of the average seems to be the driver behind cerebral hypometabolism . The way I describe it to my patients is it's like slow brain energy .
So the decline in estrogen starting around age 4043 is kind of the average seems to be the driver behind cerebral hypometabolism . The way I describe it to my patients is it's like slow brain energy . So you walk into a room , you can't remember why .
