How Nicotine Impacts Your Brain & Enhances Focus | Dr. Andrew Huberman

And that will point to avenues as to how to quit or reduce intake . And it also points to how nicotine can actually be used in an antidepressant way should you choose ? And we will talk about what the various criteria are for choosing that , but just understand nicotine increases motivation , it decreases negative feelings of mood , it increases positive feelings of mood and motivation .

How Nicotine Impacts Your Brain & Enhances Focus | Dr. Andrew Huberman

Now , here's what's very important nicotine triggers the release of dopamine from the nucleus accumbens . This is what gives nicotine , it's rewarding properties , it increases motivation , it tends to give a not so subtle but very transient increase in feelings of well being and alertness and motivation . And that's because of the increase in dopamine caused by nicotine directly within the nucleus .

How Nicotine Impacts Your Brain & Enhances Focus | Dr. Andrew Huberman

And it also points to how nicotine can actually be used in an antidepressant way should you choose ? And we will talk about what the various criteria are for choosing that , but just understand nicotine increases motivation , it decreases negative feelings of mood , it increases positive feelings of mood and motivation .

How Nicotine Impacts Your Brain & Enhances Focus | Dr. Andrew Huberman

This is why so many billions of people ingest nicotine in one form or another . It's also why nicotine is so hard to quit because there's a potent increase in dopamine from multiple neural circuit pathways within this mesolimbic reward circuitry . Now , within the mesolimbic reward circuitry , there's an interesting feature , there are accelerators that essentially push out more dopamine , get more dopamine released and there are breaks of the so called Gaba ergic variety .

How Nicotine Impacts Your Brain & Enhances Focus | Dr. Andrew Huberman

Accumbens . Nicotine also triggers the release of certain neurochemicals from the ventral tegmental area itself . And those impinge on nucleus a commons and increase dopamine levels further .