And of course , the right metric is not what percent of the population , which of course includes Children , things like that . It's , you know , so the function of age is age , the major risk factor for having Alzheimer's , we stay with glaucoma a disease I'm much more familiar with because my lab worked on it for many years . The biggest risk factor for getting glaucoma is age .
Um Anyway , the um the E three isoform I think showed up God , I think 50,000 years ago and the E two isoform showed up very recently about 10,000 years ago . Now , today we realize that there's a clear stratification of risk when it comes to Alzheimer's disease that tracks with those isoforms . So because you have two copies , you basically have six combinations of how you can combine those genes .
And what's perhaps most devastating about those genes is how early the onset is of the disease . These are people that are usually getting Alzheimer's disease in their fifties . Um So we do have a patient in our practice .
Irrespective of whether or not we get what is called Alzheimer's dementia . So Alzheimer's disease is both the most prevalent form of dementia and the most prevalent neurodegenerative disease . So it occupies that unique spot .
Uh One is called Psen one , another , one is called Psen two and another one is called A PP . Those genes collectively make up about 1% of cases of people with Alzheimer's disease . So they're fortunately very rare genes .
