OZEMPIC: Stephan Guyenet, PhD talks about the neurology of obesity

I have a phd in Neurobiology from the University of Washington and I've been doing research for about 11 years and publishing uh my thoughts online as well . Fundamentally , excess fat , mass obesity , overweight those conditions as far as we know . Well , I mean , this is just thermodynamic fact , it's caused by more energy entering the body than energy exiting the body .

OZEMPIC: Stephan Guyenet, PhD talks about the neurology of obesity

Well , I mean , this is just thermodynamic fact , it's caused by more energy entering the body than energy exiting the body . But that doesn't necessarily get us that far in terms of thinking about what obesity is , what's causing it and how to reverse it . Anthony Scni , who did some work in rats back in the 19 seventies and they were trying to produce dietary obesity in rats so they could study obesity .

OZEMPIC: Stephan Guyenet, PhD talks about the neurology of obesity

And instead they will eat chips and cookies and salami and , and peanut butter and whatever , you know , fruit loops , whatever palatable calorie , dense foods you put in there and we diverged from rodents evolutionarily tens of millions of years ago . So , whatever these pathways are that are operating that are causing us to overeat , they're extremely ancient . So these are extremely deeply seated uh brain adaptations .

OZEMPIC: Stephan Guyenet, PhD talks about the neurology of obesity

And so how do you do that ? Well , you can feed them a high fat diet that will cause them to gain fat . But Sloan had this kind of novel idea that as far as I know , no one had ever tried this before .

OZEMPIC: Stephan Guyenet, PhD talks about the neurology of obesity

But that doesn't necessarily get us that far in terms of thinking about what obesity is , what's causing it and how to reverse it . Anthony Scni , who did some work in rats back in the 19 seventies and they were trying to produce dietary obesity in rats so they could study obesity . So at the time they were , they were trying to develop a reliable model so that grad students didn't have to , you know , wait a year to get fat rats .