Testosterone & Testosterone Replacement Therapy (TRT) | Dr. Peter Attia & Dr. Andrew Huberman

And do you still use antibiotics ? Uh , um , sorry to try and lower SHBG because it's too potent . No , because it's just too complicated for patients .

Testosterone & Testosterone Replacement Therapy (TRT) | Dr. Peter Attia & Dr. Andrew Huberman

So , except in the opposite direction . So higher estra dial is higher SHBG . Um So again , occasionally you'll see a guy with incredi normal testosterone , but he's a very high aromatase activity person .

Testosterone & Testosterone Replacement Therapy (TRT) | Dr. Peter Attia & Dr. Andrew Huberman

So a micro dose of this has to be small enough that it doesn't impair your body's ability to make testosterone . But Anavar has such a high affinity for SHBG that it basically distracts your shbd from binding your testosterone freeing up testosterone . That's exactly right .

Testosterone & Testosterone Replacement Therapy (TRT) | Dr. Peter Attia & Dr. Andrew Huberman

So genetics plays a huge role in this . There's no question that just out of the box , people have a different like set point for SHBG . Mine is incredibly low .

Testosterone & Testosterone Replacement Therapy (TRT) | Dr. Peter Attia & Dr. Andrew Huberman

So he has a lot of the enzyme that converts testosterone into estradiol . You can lower estradiol a bit with an aromatase inhibitor and that can bring down SHPG . Now , again , these things individually are rarely enough to move the needle .