Testosterone & Testosterone Replacement Therapy (TRT) | Dr. Peter Attia & Dr. Andrew Huberman

So I do wanna acknowledge that . But with that in mind , how do you think about and perhaps occasionally prescribe uh and direct your patients in terms of hormone replacement therapy in men person , in their thirties , person , in their forties , who's doing almost all the other things correctly . Uh What sorts of levels do you think are meaningful ?

Testosterone & Testosterone Replacement Therapy (TRT) | Dr. Peter Attia & Dr. Andrew Huberman

I love to talk a little bit about hormone replacement therapy in men . Um When one looks on social media and the internet , there seems to be a younger and younger cohort of guys and people in their teens and twenties showing up to the table thinking uh that injecting testosterone cate or taking Anno VR or whatever it is is going to be the right idea .

Testosterone & Testosterone Replacement Therapy (TRT) | Dr. Peter Attia & Dr. Andrew Huberman

But then you get into a little bit of the vicious cycle of will having a normalized testosterone facilitate you doing those things better . So , uh let's just assume we come to the decision that this , this , this person is uh a good candidate for , for testosterone replacement therapy . The next question is , what's the method we're going to do it ?

Testosterone & Testosterone Replacement Therapy (TRT) | Dr. Peter Attia & Dr. Andrew Huberman

This shouldn't be surprising by the way , given the role muscles play as a glucose reservoir and a glucose sink . So now I include that as one of the things that we will consider as a factor for using testosterone . Now again , it's not the only one .

Testosterone & Testosterone Replacement Therapy (TRT) | Dr. Peter Attia & Dr. Andrew Huberman

Yeah , I mean , I think the easiest way to go about doing this is just give the hormone that's , that's missing without attention to where it's where the deficiency is . Why this becomes relevant is if you have a 35 year old guy whose testosterone is low , but you can demonstrate that it's low because he's not getting enough of a signal from the pituitary . Why would you bother giving him more testosterone when he has the capa , he has the latest cells and the Cerulli cells to make testosterone , he just needs the signal .