What Is Perimenopause? | Dr.Sara Gottfried & Dr. Andrew Huberman

And we've got all of these women that are marching toward potentially a greater risk of Alzheimer's disease . And they have this opportunity in their forties and their fifties to take hormone therapy and they may not be offered it because the typical conventional approach based on wh I is to say , unless you're having hot flashes and night sweats that are severe , I'm not gonna give you hormone therapy . And I , I just want to call that out .

What Is Perimenopause? | Dr.Sara Gottfried & Dr. Andrew Huberman

Now , there's the the G protein coupled estrogen receptors and those are mixed angiolytic angiogenic . So , um there's this whole period of perimenopause and what's most fascinating to me and we've got to talk about this either today or another time is that there is this massive massive change that happens in the female brain that people are not talking about enough . And so looking at the work of Lisa Mosconi at Cornell from uh starting around age 40 there is this massive change in cerebral metabolism .

What Is Perimenopause? | Dr.Sara Gottfried & Dr. Andrew Huberman

To me , this problem is not just menopause . What's more interesting is to talk about perimenopause . So , perimenopause is the the period of time before your final menstrual cycle .

What Is Perimenopause? | Dr.Sara Gottfried & Dr. Andrew Huberman

What's more interesting is to talk about perimenopause . So , perimenopause is the the period of time before your final menstrual cycle . And for most women , depending on how attuned you are to the symptoms , it can last for 10 years .

What Is Perimenopause? | Dr.Sara Gottfried & Dr. Andrew Huberman

They are a biomarker of changes in the brain . Uh So many of these symptoms that occur in perimenopause are not driven by the ovaries , they are driven by the brain .